Process for producing amides using catalytic amounts of an N-hyd

Details Process for producing amides using catalytic amounts of an N-hyd Process for producing amides using catalytic amounts of an N-hyd

1994-02-15

1996-07-16

Chan, Christina Y.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

530333, 530341, A61K 3805

Patent

active

055368166

ABSTRACT:
A process for the manufacture of amides, including peptides, by reacting a carboxylic acid with a primary or secondary amine in the presence of a carbodiimide and a catalytic amount of a N-hydroxy compound.

REFERENCES:
patent: 3872074 (1975-03-01), Konig
Bodanszky, Principles of Peptide Synthesis, Springer-Verlag Chapter 1.1 pp.170-185-(1993).
Konig, et al. Eine neue Methode zur Synthese von peptiden: Aktivierung der Carboxyl mit Dicyclohexylcarbodiimid unter Zusatz von 1-Hydroxy-benzotriazolen, Chem. Ber 103, pp. 788-798 (1970).
Przybylski, et al Influence Of Additives On Supression Of Racemization In Peptide Synthesis Part I, Isonitroso Compounds And N-Arylsulfonyhydroxylamines As Additives Suppressing Racemization Of Amino Acides Rests In Peptide Synthesis by The DCCI Method, Roczniki Chemii, Ann. Soc. Chim. Polonorum Bd. 51, Nr. 5 pp. 939-949 (1977).

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