Process for producing amides using catalytic amounts of an N-hyd

Details Process for producing amides using catalytic amounts of an N-hyd Process for producing amides using catalytic amounts of an N-hyd

1996-02-23

1998-05-12

Lukton, David

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

530333, 530341, C07K 108

Patent

active

057506493

ABSTRACT:
A process is disclosed for the manufacture of amides, including peptides, in which a carboxylic acid is reacted with a primary or secondary amine in the presence of a carbodiimide and a catalytic amount of N-hydroxy compound.

REFERENCES:
patent: 3872074 (1975-03-01), Konig
patent: 5536816 (1996-07-01), Hohler
patent: 5580981 (1996-12-01), Carpino
Konig, et al. Eine neue Methode zur Synthese von peptiden: Aktivierung der Carboxyl mit Dicyclohexylcarbodiimid unter Zusatz von 1-Hydroxy-benzotriazolen, Chem. Ber 103, pp. 778-798 (1970).
Przybylski, et al Influence of Additives On Supression Of Racemization In Peptide Synthesis Part I, Isonitroso Compounds And N-Arylsulfonyhydroxylamines As Additives Suppressing Racemization Of Amino Acides Rests In Peptide Synthesis by The DCCI Method, Roczniki Chemii, Ann. Soc. Chim. Polonorum Bd. 51, Nr. 5 pp. 939-949 (1977).
Bodanszky, Principles of Peptide Synthesis, Springer-Verlag Chapter 1.1 pp. 170-185.

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