Process for producing amide compounds

Details Process for producing amide compounds Process for producing amide compounds

2005-02-01

2005-02-01

Lilling, Herbert J. (Department: 1651)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing nitrogen-containing organic compound

C435S227000, C435S228000, C435S232000

Reexamination Certificate

active

06849432

ABSTRACT:
The invention is a process for continuously producing an amide compound by reacting a microorganism fungus body containing nitrile hydratase or a processed product of the microorganism fungus body with a nitrile compound in an aqueous medium, characterized in that after contacting said fungus body or said processed product of said fungus body with said nitrile compound in said aqueous medium, a reaction solution thus obtained is further subjected to reaction under conditions having a plug flow region, and according to the invention, an amide compound aqueous solution of a high concentration a high purity can be easily obtained in an extremely high conversion rate of a nitrile compound without a condensation process.

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Cheo Young et al., “Continuous Production of Acrylamide Using Immobilized Brevibacterium sp. CH2 in a Two-Stage Packed Bed Reactor”, Biotechnol. Lett., vol. 12, No. 1, pp. 23-28, 1990.

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