Process for producing .alpha.-(trifluoromethyl)arylacetic acid

Details Process for producing .alpha.-(trifluoromethyl)arylacetic acid Process for producing .alpha.-(trifluoromethyl)arylacetic acid

1996-03-12

1997-09-30

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C 5334

Patent

active

056727429

ABSTRACT:
.alpha.-(trifluoromethyl)arylacetic acid for use as raw materials for medicines, agricultural chemicals, liquid crystals etc. or reagents for determining an optical purity is readily obtained through very simple reaction steps, i.e. by reacting a perfluoro(2-methyl-1,2-epoxypropyl)ether compound obtainable by ozone, oxidation of a heptafluoroisobutenyl ether compound with an aromatic compound ArH to afford an .alpha.,.alpha.-bis(trifluoromethyl)arylacetic acid ester, followed by decarboxylation and hydrolysis of the resulting ester compound.

REFERENCES:
Aaron et al., "Resolution and Configuration of .alpha.-Substituted Phenylacetic Acids" Journal of Organic Chemistry, vol. 32, pp. 2797-2803 (1967).
Middleton et al., "The Synthesis of Antiinflammatory .alpha.-(Triflouromethyl)Arylacetic Acids", Journal of Fluorine Chemistry, vol. 22, pp. 561-574 (1983).
Everett et al., "Preparation of .alpha.-Trifluoromethyl Esters From Malonic Esters", Journal of Organic Chemistry, vol. 49, pp. 3702-3706 (1984).
Muzard et al., "Fluorinated Ketene Dithioacetals; 1, Preparation and Application to the Synthesis of .alpha.-Trifluoromethylthiocarboxylic S-Esters and Aldehyde Derivatives", Synthesis, vol. pp. 965-968 (1992).
No. 69 Spring Annual Meeting Preprints II, pp. 1080 of Chemical Society of

Affiliated with

Also associated with

Rating

Process for producing .alpha.-(trifluoromethyl)arylacetic acid does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for producing .alpha.-(trifluoromethyl)arylacetic acid, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for producing .alpha.-(trifluoromethyl)arylacetic acid will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2257844