Process for producing .alpha.-L-aspartyl-L-phenylalanine methyl

Details Process for producing .alpha.-L-aspartyl-L-phenylalanine methyl Process for producing .alpha.-L-aspartyl-L-phenylalanine methyl

1986-02-25

1988-07-26

Phillips, Delbert R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 41, 426548, C07C 9912, C07C10352

Patent

active

047601647

ABSTRACT:
A process for preparing an .alpha.-L-aspartyl-L-phenylalanine methyl ester which comprises the steps of reacting formyl-L-aspartic anhydride with L-phenylalanine in the presence of water at a high pH, to produce formyl-.alpha.-L-aspartyl-L-phenylalanine; removing the formyl group from the formyl-.alpha.-L-aspartyl-L-phenylalanine and esterifying the resultant compound with methanol and hydrogen chloride to produce the hydrogen chloride salt of .alpha.-L-aspartyl-L-phenylalanine methyl ester; neutralizing the hydrogen chloride salt of .alpha.-L-aspartyl-L-phenylalanine methyl ester; and filtering the neutralized solution to produce .alpha.-L-aspartyl-L-phenylalanine methyl ester.

REFERENCES:
patent: 3933781 (1976-01-01), Bachman et al.
patent: 4348317 (1982-09-01), Bachman

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