Process for producing .alpha.-aspartyl-phenylalanine ester

Details Process for producing .alpha.-aspartyl-phenylalanine ester Process for producing .alpha.-aspartyl-phenylalanine ester

1986-12-16

1988-03-08

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C07C10102

Patent

active

047300760

ABSTRACT:
The present invention relates to a process for producing .alpha.-aspartyl-phenylalanine ester represented by the general formula ##STR1## wherein R' represents an alkyl group having 1 to 4 carbon atoms, by reducing an N-protected-N-hydroxymethyl-.alpha.-aspartyl-phenylalanine ester represented by the general formula ##STR2## wherein R represents an organic mioety which can be substituted reductively by hydrogen, and R' is as defined above, with hydrogen gas or formic acid, in the presence of a reduction catalyst and an aromatic primary amine. According to the present invention, there can be obtained a high purity .alpha.-aspartyl-phenylalanine ester with a high yield.

REFERENCES:
patent: 3879372 (1975-04-01), Boesten
patent: 3933781 (1976-01-01), Bachman et al.
patent: 4021418 (1977-05-01), Takemoto et al.
Geiger et al., Chem. Ber. 102,2487-2490 (1969).

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