Process for producing alanylgutamine

Details Process for producing alanylgutamine Process for producing alanylgutamine

1993-10-27

1995-01-10

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

558 50, C07C22900

Patent

active

053809343

ABSTRACT:
Disclosed is a process for producing alanylglutamine, which comprises reacting an N-(2-substituted)-propionylglutamine compound represented by the formula (I): ##STR1## where X represents halogen, alkylsulfonyloxy, or substituted or unsubstituted arylsulfonyloxy, with ammonia at a temperature of 60.degree. C. or below.
In accordance with the present invention, highly purified alanylglutamine can be produced in a high yield, without racemization.

REFERENCES:
Greenstein, "Chemistry of the Amino Acids", vol. 1, pp. 700-703 & 712-714; and vol. 2, pp. 808-816 & 1272-1295 (1961).
March, "Advanced Organic Chemistry: Reactions, Mechanisms, and Sturcutre", 4th Ed., pp. 411-413 (1992).
Y Ogata, et al., Bull. Chem. Soc. Jpn., vol. 54, No. 11 (1981) 3605-06.
Chemical Abstracts, vol. 99, No. 1 (1983) 6016a.
Shimonishi et al., Bull. Chem. Soc. J., vol. 35 (1962) 1966-70.
Shimonishi et al., Bull. Chem. Soc. J., vol. 37 (1964) 200-3.
Akibori et al., Bull. Chem. Soc. J., vol. 34 (1961) 739.
Thierfelder et al., Hoppe-Seyler's Z. Phys. Chem., vol. 105 (1919) 58-82.

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