Process for producing alanylglutamine

Details Process for producing alanylglutamine Process for producing alanylglutamine

1994-09-19

1996-08-27

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C22900

Patent

active

055502830

ABSTRACT:
Disclosed is a process for producing alanylglutamine, which comprises reacting an N-(2-substituted)-propionylglutamine compound represented by the formula (I): ##STR1## where X represents halogen, alkylsulfonyloxy, or substituted or unsubstituted arylsulfonyloxy, with ammonia at a temperature of 60.degree. C. or below.
in accordance with the present invention, highly purified alanylglutamine can be produced in a high yield, without racemization.

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Akabori et al., Bull. Chem. Soc. J., vol. 34 (1961) 739.
Thierfelder et al., Hoppe-Seyler's Z. Phys. Chem., vol. 105 (1919) 58-82.
Chemical Abstracts, vol. 99, No. 1 (1983) 6016a.
Y. Ogata et al., Bull. Chem. Soc. Jpn., vol. 54, No. 11 (1981) 3605-06.
Mar., Advanced Organic Chemistry, 4th Edition (1992) 411-413.
Greenstein, Chemistry of the Amino Acids, vol. 1 (1961) 700-703; 712-714; vol. 2 (1961) 808-816; 1272-1295.

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