Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for...
Reexamination Certificate
2007-02-13
2007-02-13
Tsang, Cecilia J. (Department: 1654)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
C424S001690
Reexamination Certificate
active
10736793
ABSTRACT:
The invention is a process for purifying TAFIa from a serum sample in the presence of a reversible inhibitor of TAFIa. The invention is also a method of measuring the activity of TAFIa in the presence of a reversible inhibitor.
REFERENCES:
Boffa et al., Plasma and recomb. thrombin-activable fibrinol. inhibitor (TAFI) and activatt TAFI comp. with respect to glycosyl., thromb./thrombom..- depend. activ., thermal stability, and enzym. properties. J Biol Chem. Jan. 23, 1998;273(4):2127-35. (InIDS).
Bajzar et al. Purification and charaterization of TAFI, a thrombin-activable fibrinolysis inhibitor. J. of Biol. Chem., 270(24), pp. 14477-14484, 1995.
D. Hendricks, et al., J. Clin. Chem. Clin. Biochem. 27, 277-285.
S-S. Mao, et al., J. Biol. Chem. 274, 35046-35052.
W. Wang, et al., J. Biol. Chem. 269, 15937-15944.
D. Hendricks, et al., Biochim. Biophy Acta 1034, 86-92.
M. B. Boffa, et al., J. Biol. Chem. 273, 2127-2135.
Colussi Dennis
Gardell Steve
Mao Shi-Shan
Audet Maury
Camara Valerie J.
Merck & Co. , Inc.
Parr Richard S.
Tsang Cecilia J.
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