Process for producing a transglutaminase derived from streptomyc

Details Process for producing a transglutaminase derived from streptomyc Process for producing a transglutaminase derived from streptomyc

1991-08-26

1993-10-12

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using a micro-organism to make a protein or polypeptide

435193, 435227, 435 711, C12P 2104, C12N 910, C12N 978

Patent

active

052524698

ABSTRACT:
A process for producing a transglutaminase which comprises (1) culturing a microorganism having the identifying characteristics of a microorganism selected from the group consisting of Streptomyces sp. No. 83, deposited as FERM BP-3505, Streptomyces lavendulae No. 466, deposited as FERM BP-3506, and mutants thereof, wherein the microorganism is capable of producing a transglutaminase, wherein the transglutaminase is an enzyme which catalyzes an acyl transfer reaction of a .gamma.-carboxyamide group of a glutamine residue in a peptide or protein chain in the presence or absence of Ca.sup.++ and wherein the transglutaminase has an isoelectric point of 10 or 6.8, respectively, and is inhibited by Pb ions, and (2) recovering the transglutaminase from the culture obtained is disclosed.

REFERENCES:
patent: 5055310 (1991-10-01), Nonaka et al.
patent: 5156956 (1992-10-01), Motoki et al.
Goodfellow et al. (1984) "The Biology of the Actinomycetes", pp. 16-17, Acad. Press, N.Y.
ATCC Catalog of Bacteria & Bacteriophages (1989) 17th Ed., pp. 229, 246-247.

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