Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1996-09-19
1998-05-12
Degen, Nancy
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
43525233, C12P 2102, C12P 1930, C12P 1934, C12N 121
Patent
active
057503680
ABSTRACT:
The invention relates to a process for producing a desired substance by culturing a transformant in a medium until the desired substance is accumulated in the culture and then recovering the desired substance, the transformant being obtained by transforming an acetic acid-resistant microorganism of the genus Escherichia with a recombinant plasmid carrying a gene involved in production of the desired substance. The present process enables cells to be cultured easily at high density while the desired substance can be efficiently produced.
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Applied Biochemistry and Biotechnology, vol. 34/35, pp. 185-204, 1992, H.G. Lawford, et al., "Effect of Acetic Acid on Xylose Conversion to Ethanol By Genetically Engineered E. coli".
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Youl Lark Lee, et al., "High Cell Density Culture of a Recombinant Escherichia coli Producing Penicillin Acylase in a Membrane Cell Recycle Fermentor". Biotechnology and Bioengineering, vol. 36, pp. 330-337, 1990.
Toru Matsui, et al., "Pressurized Culture of Escherichia coli for a High Concentration", Agric. Biol. Chem., vol. 53, pp. 2215-2120, 1989.
J.C. Diaz-Ricci, et al., "Effect of Alteration of the Acetic Acid Synthesis Pathway on the Fermentation Pattern of Escherichia coli", Biotechnology and Bioengineering, vol. 38, pp. 1318-1324, 1991.
Masahiro Fukaya, "Cloning of Genes Responsible for acetic Acid Resistance in Acetobacter aceti", Journal of Bacreriology, pp. 2096-2104, Apr. 1990.
Seo, et al, "Glucose-Limited Fed-Batch Culture of Escherica coli for Production of Recombinant Human Interleukin-2 with the DO-Stat Method", Journal of Fermentation and Bioengineering, vol. 74, No. 3, pp. 196-198, 1992.
Anazawa Hideharu
Nakagawa Satoshi
Oda Hideki
Degen Nancy
Kyowa Hakko Kogyo Co. Ltd.
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