Process for producing a soluble rubella antigen

Details Process for producing a soluble rubella antigen Process for producing a soluble rubella antigen

1978-01-31

1980-03-25

Fagelson, Anna P.

Drug, bio-affecting and body treating compositions

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Taste or smell or chemical irritation to the eye, nose, or...

260112R, 260112B, 424 8, 424 86, 424 89, 435 7, 435239, C12K 104, C12K 700, G01N 3316, A61K 3920

Patent

active

041950747

ABSTRACT:
Purified soluble antigen, specific for rubella virus, is isolated from growth media of rubella-infected cell cultures by affinity and gel permeation chromatography and characterized, inter alia, by its specific activity. Antigen-sensitized particles are employed as immunoassay reagents in, for example, agglutination assays for detection and quantification of rubella antibodies in body fluids such as serum, spinal fluid and the like.

REFERENCES:
Lowe, Affinity Chromatography, John Wiley & Sons, NY, 1974, pp. 44-56, 150-156, 165-166.
Salmi, Acta Path. & Micro Scand. Sect. B, Microbiol., vol. 80, No. 4, 1972, pp. 545-558.
Hassan, PSEBM, vol. 125, 1967, pp. 430-435.
LeBouvier, Nature, vol. 221, Jan. 4, 1969, pp. 78-79.
Salmi, Chem. Abs., vol. 78, 1973, Ab. No. 14295x.
Desyatskova, Chem. Abs., vol. 78, 1973, Ab. No. 70122a.
Chappel, The J. of Exptl. Med., vol. 139, 1974, pp. 497-511.
Schmidt, PSEBM, vol. 123, 1966, pp. 758-762.
Liebhaber, Virology, vol. 47, 1972, pp. 684-693.
Safford & Whittington, Fed. Proceedings, vol. 35, No. 3, Mar. 1, 1976, Ab. No. 3351, p. 813.

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