Process for producing a slow release composite

Details Process for producing a slow release composite Process for producing a slow release composite

1983-07-15

1986-04-15

Williams, Howard S.

Coating processes

Medical or dental purpose product; parts; subcombinations;...

Particulate or unit-dosage-article base

20415768, 424 19, 427 531, 427 541, 427 44, 524704, 264 433, 264 47, A01N 101, B01J 1912, B05D 306

Patent

active

045827192

ABSTRACT:
A process is, herein disclosed, for producing a slow release composite having a physiologically active substance encapsulated therein, which comprises preparing a system wherein one or more physiologically active substances are in contact with protein from one or more protein sources, and bringing said system into direct contact with steam at temperatures between 50.degree. C. and 100.degree. C. to denature the protein and make the same hydrophobic, to thereby make a slow release composite having the physiologically active substance dispersed, fixed and encapsulated therein. And a process is also disclosed for producing a slow release composite which comprises preparing a mixture of one or more hydrophilic polymerizable monomers containing the body fluid and/or isotonic solution, protein from one or more protein sources, and one or more physiologically active substances, subjecting the mixture to direct contact with steam and irradiation with light or ionizing radiation, said treatment with steam being performed either before or simultaneously with irradiation with light or ionizing radiation.

REFERENCES:
patent: 3955012 (1976-05-01), Okanura et al.
patent: 3962416 (1976-06-01), Katzen

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