Process for producing a polyene antibiotic

Details Process for producing a polyene antibiotic Process for producing a polyene antibiotic

1990-04-26

1993-09-14

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Processes of making, purifying or recovering

A61K 3574

Patent

active

052446611

ABSTRACT:
By irradiating a polyene antibiotic having a cis-type polyene structure with long wavelength ultraviolet light, it is possible to prepare the corresponding antibiotic having a trans-type polyene structure in high yield in a simple manner. Such antibiotics having a trans-type polyene structure exhibit strong antimicrobial activities and are useful as drugs for humans or animals.

REFERENCES:
patent: 3773925 (1973-11-01), Benzzese et al.
patent: 3793448 (1974-02-01), Schaffner et al.
patent: 4642318 (1987-02-01), Wolff
Canadian Journal of Chemistry, vol. 63, No. 1, Jan. 1985, pp. 77-85; N. O. Petersen: "Intramolecular fluorescence energy transfer in nitrobenzoxadiazole derivatives of polyene antibodies".

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