Process for producing a pharmaceutical solid preparation...

Details Process for producing a pharmaceutical solid preparation... Process for producing a pharmaceutical solid preparation...

2005-03-29

2005-03-29

Theisen, Mary Lynn (Department: 1732)

Plastic and nonmetallic article shaping or treating: processes

Formation of solid particulate material directly from molten...

Coated particles

C264S013000, C264S014000, C264S117000, C427S002140, C427S002150, C427S002160

Reexamination Certificate

active

06872336

ABSTRACT:
Among the conventional processes for producing solid dispersion, the solid dispersion obtained by a solvent method is excellent in terms of solubility and bioavailability of a poorly soluble drug. However, due to frequent uses of organic solvents in the solvent method, problems have arisen such as organic solvent residue in products, environmental pollution and operational safety as well as corporate problems such as capital investment and the like required to avoid such events. The present invention provides a process for preparing pharmaceutical solid preparations without use of organic solvents frequently used in conventional solvent methods. Specifically, the present invention provides a process for producing a pharmaceutical solid preparation, which is formulated by spraying a solution wherein a poorly soluble drug is dissolved in a plasticizer, and an aqueous solution and/or water dispersion of a water-soluble polymer from nozzle outlets simultaneously and separately in the process for producing the pharmaceutical solid preparation.

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