Process for producing a multi-layered slow release composite

Details Process for producing a multi-layered slow release composite Process for producing a multi-layered slow release composite

1981-02-10

1982-11-16

Lusignan, Michael R.

Coating processes

Medical or dental purpose product; parts; subcombinations;...

Particulate or unit-dosage-article base

424 19, 424 21, 424 33, 427 3, 427 36, 427 531, 427214, 427222, 4273981, 428407, A01N 102, B05D 300, B05D 306

Patent

active

043594832

ABSTRACT:
A process is herein disclosed for producing a multi-layered slow release composite comprising: a first step wherein one or more physiologically active substances is mixed with one member selected from the group consisting of one or more supercooling polymerizable vinyl monomers, one or more natural or synthetic polymeric substances and a mixture thereof, and the mixture is given a predetermined shape and subjected to a physical treatment to form a slow release composite; a second step wherein a predetermined thickness of coating of one member selected from the group consisting of one or more supercooling polymerizable vinyl monomers, one or more natural or synthetic polymeric substances and a mixture thereof is formed on the surface of said slow release composite, which then is subjected to a physical treatment so that a layer wherein no physiologically active substance is encapsulated is formed on the surface of said slow release composite; a third step wherein a predetermined thickness of coating of a mixture of one or more physiologically active substances with one member selected from the group consisting of one or more supercooling polymerizable vinyl monomers, one or more natural or synthetic polymeric substances and a mixture thereof is formed on the surface of the slow release composite having the layer provided in the second step wherein no physiologically active substance is encapsulated, said composite then is subjected to a physical treatment to form a layer wherein the physiologically active substance is encapsulated.

REFERENCES:
patent: 4252786 (1981-02-01), Weiss et al.
patent: 4267138 (1981-05-01), Dobo et al.
patent: 4282287 (1981-08-01), Grese
patent: 4289795 (1981-09-01), Bogentoft et al.

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