Process for producing a lipoprotein-poor concentrate of coagulat

Details Process for producing a lipoprotein-poor concentrate of coagulat Process for producing a lipoprotein-poor concentrate of coagulat

1983-12-02

1984-09-25

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

260112B, A61K 3516

Patent

active

044735537

ABSTRACT:
There is disclosed a process for producing coagulation factors VII and VIIa in relatively high purity by contacting an aqueous preparation containing factors VII and VIIa with a lipoprotein binding adsorbent and separating the coagulation factors and other proteins therefrom, contacting the resulting lipoprotein-poor solution with a divalent metal salt adsorbent having selective affinity for calcium-binding coagulation factors and eluting the coagulation factors therefrom, and contacting the eluate with an anionic exchange resin and selectively eluting coagulation factors VII and VIIa therefrom by step or gradient elution techniques to obtain factors VII and VIIa free of other coagulation factors and other proteins.

REFERENCES:
patent: 4357321 (1982-11-01), Thomas
Chem. Abst. 10th Collect. Index vol. 86-95 (1977-1981) Chemical Substances, pp. 10380cs & 10381cs.

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