Process for producing a guanidine derivative

Details Process for producing a guanidine derivative Process for producing a guanidine derivative

1989-03-09

1990-01-30

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D23364

Patent

active

048974919

ABSTRACT:
The guanidine derivative represented by the formula [III], ##STR1## (commonly known under the name "Cimetidine") is produced by reaction of the compound represented by the formula [I], ##STR2## with a compound represented by the formula [II], ##STR3## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6, is each hydrogen atom, a lower alkyl group, phenyl group, or a radical of --OR.sub.7 or --COOR.sub.7, in which R.sub.7 is hydrogen atom, a lower alkyl group or an alkali metal, followed by reaction with methylamine.

REFERENCES:
patent: 3755363 (1973-08-01), Timmons et al.
patent: 3950353 (1976-04-01), Durant et al.
patent: 4220654 (1980-09-01), Bolhofer et al.
A. Omura, et al., Bull. Chem. Soc. Japan, 50(4), 914-916 (1977).

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