Process for producing a fluorine-containing compound

Details Process for producing a fluorine-containing compound Process for producing a fluorine-containing compound

2005-06-07

2005-06-07

Tsang, Cecilia J. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C570S123000, C570S127000, C570S131000, C570S134000

Reexamination Certificate

active

06903230

ABSTRACT:
It is to provide a process for synthesizing an intended fluorine-containing compound having a geminal difluoro structure with a high yield, by subjecting a carbonyl compound which is readily available to a two-stage reaction.A compound (1) such as ethyl 4-oxocyclohexanecarboxylate is reacted with a compound of the formula X-Z or a compound of the formula Z2O (wherein Z is a monovalent group which gives a leaving group of the structure —OZ, and X is a chlorine atom, a bromine atom or an iodine atom) such as phosphorus pentachloride, and then a fluorinating agent which generates fluorine anions such as HF is acted thereon to obtain a fluorine-containing compound (2) such as ethyl 4,4-difluorocyclohexanecarboxylate

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