Process for producing a concentrate enriched in coagulation fact

Details Process for producing a concentrate enriched in coagulation fact Process for producing a concentrate enriched in coagulation fact

1984-10-15

1987-01-20

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

A61K 3516

Patent

active

046379320

ABSTRACT:
There is disclosed an improved process for producing a concentrate containing coagulation factors VII and VIIa in relatively high purity by contacting an aqueous preparation containing factors VII and VIIa with a divalent metal salt adsorbent having selective affinity for calcium-binding coagulation factors and eluting the coagulation factors therefrom, and contacting the eluate with an anionic exchange resin and selectively eluting coagulation factors VII and VIIa therefrom by step or gradient elution techniques to obtain factors VII and VIIa in high yield, free of other coagulation factors and other proteins. In one embodiment of this invention Cohn Effluent I may be used as the source of factors VII and VIIa.

REFERENCES:
patent: 4456591 (1984-06-01), Thomas
patent: 4470969 (1984-09-01), Pancham
patent: 4473553 (1984-09-01), Zuffi et al.
patent: 4479938 (1984-10-01), Thomas

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