Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1995-02-03
1996-08-06
Fleisher, Mindy
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
435 696, A61K 3514, G07K 1107, G07K 14755, C12P 2104
Patent
active
055435025
ABSTRACT:
A coagulation active complex of Factor VIII fragments is produced by causing a coagulation inactive FVIII heavy chain to react with a coagulation inactive FVIII light chain in the presence of a complex forming agent. Thus, FVIII-HC and FVIII-LC are converted to coagulation active FVIII complex in the presence of metal ions, such as Mn.sup.2+, Ca.sup.2+, or Co.sup.2+ or a component of the prothrombin complex or a substance having reactivity to compounds containing the group --SH and/or --S--S.
REFERENCES:
Vehar et al. 1984 Nature 312:337-342.
Eaton et al. 1986 Prog Hemostas. Thromb 8:47-70.
Truett et al. 1988 DNA 4(5):333-349.
Siepes et al. 1982 "Protein Purification" 194-197.
Mikaelsson et al. Abstract No. 1012 and 0822 Thrombosis Haemostas 50(1) 1983.
Church et al (1984) Proc. Natl. Acad. Sci. 81, 6934-6937.
Fass et al. (1982) Biol. Abstr. 74,, No. 44255.
EP Search Report 5 Pages.
Nordfang Ole
Rasmussen Mirella E.
Agris, Esq. Cheryl H.
Degen Nancy J.
Fleisher Mindy
Novo Nordisk A S
Zelson Esq. Steve T.
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