Process for producing a coagulation active complex of factor VII

Details Process for producing a coagulation active complex of factor VII Process for producing a coagulation active complex of factor VII

1995-02-03

1997-03-11

Jacobson, Dian C.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530381, 930100, 435 696, A61K 3837, C07K 14745, C07K 14755

Patent

active

056102780

ABSTRACT:
A coagulation active complex of Factor VIII fragments is produced by causing coagulation inactive FVIII heavy chain to react with coagulation inactive FVIII light chain in the presence of a complex forming agent. Thus, FVIII-HC and FVIII-LC are converted to coagulation active FVIII complex in the presence of divalent metal ions, such as Mn.sup.2+, Ca.sup.2+ or C.sup.2+, or a component of the pro-thrombin complex.

REFERENCES:
D. N. Fass, et al., Blood 59(3):594-600 (1982).
D. L. Eaton, et al., Progress in Hemostasis and Thrombosis 8:47-70 (1986).

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