Process for producing a 4,6-bis(difluoromethoxy)-2-alkylthiopyri

Details Process for producing a 4,6-bis(difluoromethoxy)-2-alkylthiopyri Process for producing a 4,6-bis(difluoromethoxy)-2-alkylthiopyri

1990-07-26

1991-12-10

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D23960

Patent

active

050719823

ABSTRACT:
A process for producing a 4,6-bis(difluoromethoxy)-2-alkylthiopyrimidine, which comprises reacting a 2-alkylthiobarbituric acid and monochlorodifluoromethane in the presence of a base in an inert solvent, wherein, for a first reaction, after charging a part of the base, the rest of the base and the monochlorodifluoromethane are simultaneously introduced to obtain a mixture of a 4-difluoromethoxy-6-hydroxy-2-alkylthiopyrimidine and a 4,6-bis(difluoromethoxy)-2-alkylthiopyrimidine, and then, for a second reaction, to this mixture, the base and the monochlorodifluoromethane are again simultaneously introduced, or the base is charged first and then the monochlorodifluoromethane is introduced.

REFERENCES:
patent: 4542216 (1985-09-01), Pfluger
patent: 4692524 (1987-09-01), Hassig
patent: 4900827 (1990-02-01), Seifert et al.

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