Process for producing 7-(substituted)-8-(substituted-9-[(substit

Details Process for producing 7-(substituted)-8-(substituted-9-[(substit Process for producing 7-(substituted)-8-(substituted-9-[(substit

1994-09-27

1996-02-27

Kestler, Kimberly J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Tetracyclo naphthacene configured ring system having at...

552203, 552205, 546112, 546184, 546242, 546 68, 546496, 546505, 544 63, 544 88, 544 98, 544106, 544178, 544235, 544244, 544336, 544383, 544404, 585 22, 548 59, 548207, 548255, 5482622, 5483041, 5483351, 5483431, 5483611, 5483621, 5483711, 5483751, 548400, 548579, 548950, 548954, 548967, C07C23112, C07C23364

Patent

active

054950325

ABSTRACT:
The invention provides a process for the production of compounds of the formula: ##STR1## wherein, R, R.sup.3, R.sup.4, X and W are defined in the specification in which a compound of the following formula: ##STR2## is reacted with a nucleophile of the formula WH in an inert atmosphere in the presence of a polar-protic or a polar-aprotic solvent. The resulting compounds are useful as antibiotics.

REFERENCES:
patent: 5386041 (1995-01-01), Sum et al.
patent: 5420272 (1995-05-01), Sum et al.
Morrison and Boyd, Organic Chemistry, 4th ed, 1983, pp. 894, 898-900, 902.

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