Process for producing 7-dimethylamino-6-demethyl-6-deoxytetracyc

Details Process for producing 7-dimethylamino-6-demethyl-6-deoxytetracyc Process for producing 7-dimethylamino-6-demethyl-6-deoxytetracyc

1988-07-22

1990-04-17

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Tetracyclo naphthacene configured ring system having at...

552206, C01D 9929

Patent

active

049182080

ABSTRACT:
A process for producing 7-dimethylamino-6-demethyl-6-deoxytetracycline (minocycline) which comprises treating the reaction liquid containing minocycline and formaldehyde with hydroxylamine or urea, the reaction liquid being obtained after reductive methylation of 7-amino-6-demethyl-6-deoxytetracycline by using aldehyde, then subjecting the reaction liquid to an adsorption treatment with a nonionic adsorption resin (adsorbent), and subsequently eluting the intended product adsorbed to the adsorbent.

REFERENCES:
patent: 3226436 (1965-12-01), Petisi et al.
patent: 3403179 (1968-09-01), Zambrano
patent: 3515717 (1970-06-01), Cha et al.
patent: 3725400 (1973-04-01), Voser
J. Med. Chem., vol. 10, pp. 44, (1967), Fr. Add. No. 92,088.
I & EC Product Research & Development, 7, 107, (1968), "Amberlite XAD".

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