Process for producing 6.beta.,14.alpha.-dihydroxy-4-androstene-3

Details Process for producing 6.beta.,14.alpha.-dihydroxy-4-androstene-3 Process for producing 6.beta.,14.alpha.-dihydroxy-4-androstene-3

1993-11-19

1995-01-03

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing a...

435 61, 435 54, 435 52, 4352541, 435911, C12P 3306, C12P 3316, C12P 3302, C12N 114

Patent

active

053786114

ABSTRACT:
The invention provides a novel process for the production of 6.beta.,14.alpha.-dihydroxy-4-androstene-3,17-dione which comprises culturing a microorganism belonging to the genus Myrothecium and capable of hydrolyzing 4-androstene-3,17-dione to produce 6.beta.,14.alpha.-dihydroxy-4-androstene-3,17-dione in a medium supplemented with 4-androstene-3,17-dione, and isolating 6.beta.,14.alpha.-dihydroxy-4-androstene-3,17-dione from the cultured medium. According to the process of the present invention, 6.beta.,14.alpha.-dihydroxy-4-androstene-3,17-dione and 14.alpha.-hydroxy-4-androstene-3,6,17-trione can be produced with a high yield in a simple manner.

REFERENCES:
patent: 4382952 (1987-05-01), Bloem et al.
patent: 4999357 (1991-03-01), Gadras et al.
patent: 5180827 (1993-01-01), Gadras et al.
patent: 5258290 (1993-11-01), Weber et al.
patent: 5275949 (1994-01-01), Sakamoto et al.

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