Process for producing 6.alpha.-fluoro-.DELTA..sup.1,4 -3-keto st

Details Process for producing 6.alpha.-fluoro-.DELTA..sup.1,4 -3-keto st Process for producing 6.alpha.-fluoro-.DELTA..sup.1,4 -3-keto st

1980-07-21

1982-07-20

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26039745, 2603973, 26023955R, C07J 7100

Patent

active

043405380

ABSTRACT:
Two processes are disclosed (one-pot and two-pot) for the transformation of a 6.beta.-fluoro-.DELTA..sup.1,4 -3-keto steroid (IV) to a 6.alpha.-fluoro-.DELTA..sup.1,4 -3-keto steroid (VI). These processes permit the introduction of a fluorine atom at the 6.alpha. position of a .DELTA..sup.1,4 -3-keto steroid where previously the .DELTA..sup.1 double bond could not be introduced until after the 6.alpha.-fluorine atom was present. The 6.alpha.-fluoro-.DELTA..sup.1,4 -3-keto steroids (VI) are intermediates useful in the production of pharmacologically active steroids.

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