Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Reexamination Certificate
2011-01-11
2011-01-11
Parsa, Jafar (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
Reexamination Certificate
active
07868207
ABSTRACT:
The present invention provides a process for producing 1-(3,4-dichlorobenzyl)-5-octylbiguanide or a salt thereof, the process comprising reacting 1-cyano-3-octylguanidine or a salt thereof, with 3,4-dichlorobenzylamine or a salt thereof, in an ester-based organic solvent. According to the present invention, the reaction can be carried out at a low temperature using general-purpose equipment, and 1-(3,4-dichlorobenzyl)-5-octylbiguanide or a salt thereof can be produced in a high yield by a safe and easy process.
REFERENCES:
patent: 0 507 317 (1992-10-01), None
patent: 1 634 589 (2006-03-01), None
patent: 5-194361 (1993-08-01), None
Tsubouchi et al., “Synthesis and Structure-Activity Relationships of Novel Antiseptics”, Bioorganic & Medicinal Chemistry Letters, vol. 7, No. 13, pp. 1721-1724, (1997).
Fujita Nobuhisa
Muguruma Yasuaki
Nomi Daisuke
Okaichi Yoshihiko
Tada Nobuhito
Finnegan Henderson Farabow Garrett & Dunner L.L.P.
Otsuka Pharmaceutical Co. Ltd.
Parsa Jafar
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