Process for producing 5-fluorouracil derivative with a calcium c

Details Process for producing 5-fluorouracil derivative with a calcium c Process for producing 5-fluorouracil derivative with a calcium c

1977-03-03

1978-10-17

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D23954

Patent

active

041210379

ABSTRACT:
5-Fluorouracil derivative having the formula ##STR1## wherein R represents hydrogen atom or 2-tetrahydrofuryl group is produced by reacting more than equi-mole of 2,3-dihydrofuran with 5-fluorouracil in a polar aprotic solvent with a catalytically effective amount of a catalyst selected from the group consisting of metal halides, non-metal halides, tertiary amine salt of inorganic acids and organic acids in neutral or basic condition at 50.degree. to 150.degree. C under pressure.

REFERENCES:
patent: 4039546 (1977-08-01), Giller et al.
Ozaki et al., Chem. Abstracts, vol. 85, (1976), 192753x.
Brossmer et al., Chem. Abstracts, vol. 78, (1973), 58343r.

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