Process for producing...

Details Process for producing... Process for producing...

2011-05-17

2011-05-17

Young, Shawquia (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C564S163000

Reexamination Certificate

active

07943785

ABSTRACT:
The present invention provides a process for producing (Z)-1-phenyl-1-(N,N-diethylaminocarbonyl)-2-phthalimidomethylcyclopropane, which includes reacting (Z)-1-phenyl-1-(N,N-diethylaminocarbonyl)-2-hydroxymethylcyclopropane with an orthoester and a brønsted acid, and reacting the reaction product with a phthalimidating agent; and a process for producing (Z)-1-phenyl-1-(N,N-diethylaminocarbonyl)-2-aminomethylcyclopropane hydrochloride through the above process.

REFERENCES:
patent: 5034541 (1991-07-01), Bigg et al.
patent: 0 200 638 (1986-04-01), None
patent: 1 770 084 (2007-04-01), None
R. Guilet et al., “Improvements in procedures of a bicyclic lactone synthesis: 1-phenyl-2-oxo-3-oxa-bicyclo [3:1:0] hexane”, C.R. Avad. Sci. Paris, t. 1, Serie. II No. 2 ,1998, pp. 651-660.
B . Bonnaud, et al., “1-Aryl-2-(aminomethyl) cyclopropanercarboxylic Acid Derivatives. A new Series of Potential Antidepressants”, J. Med. Chem. 1987, vol. 30, No. 2, pp. 318-325.
B. Bonnaud, et al., “A Convenient Synthesis of Bifunctional Vicinal Cyclpropanes”, Synthesis, 1978, pp. 304-305.

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