Process for producing 4-trifluoromethylnicotinic acid

Details Process for producing 4-trifluoromethylnicotinic acid Process for producing 4-trifluoromethylnicotinic acid

1996-05-16

1998-01-13

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546318, C07D21312, C07D21308, C07D21380

Patent

active

057081751

ABSTRACT:
A process for producing 4-trifluoromethylnicotinic acid of the formula (VIII) or its salt: ##STR1## which comprises (i) a first step of reacting a halide of the formula (I):

REFERENCES:
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Synthesis, pp. 483-486, Jun. 1991, Agenor Colla, et al., "Trihaloacetylated Enol Ethers--General Synthetic Procedure and Heterocycling Ring Closure Reactions with Hydroxylamine".
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Zh. Org. Khim., vol. 26, No. 9, pp.1877-1883, 1990, I.I. Gerus, et al., ". . . Beta-Alkoxyvinyl . . . ".
Heterocycles, vol. 34, No. 7, pp. 1435-1441, 1992, E. Okada, et al., "A Facile and Convenient Synthetic Method for 3-Trifluoroacetyl-Pyrroles".
Synthesis, pp.. 533-535, Jun. 1992, E. Okada, et al., "A Facile and Convenient Synthetic Method for N-.beta.-Trifluoroacetylvinyl Amino Acid Esters, Alpha-Aminoacetophenones and Aminoacetonitriles as Potentially Useful Precursors of Fluorine-Containing Pyrroles".
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