Process for producing 4-dimethyl amino pyridine (4-DMAP)

Details Process for producing 4-dimethyl amino pyridine (4-DMAP) Process for producing 4-dimethyl amino pyridine (4-DMAP)

2005-09-06

2005-09-06

Davis, Zinna Northington (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

06939972

ABSTRACT:
An improved process for producing 4-dimethyl amino pyridine is provided. The process comprises quaternizing pyridine with a suitable quaternizing agent in the presence of organic solvent, isolating the resulting salt and aminating the salt, N-[4-pyridyl] pyridinium chloride hydrochloride, with N,N-dimethyl formamide. The resultant reaction mass is hydrolysed in the presence of a base, extracted with an aromatic solvent and distilled under vacuum to produce 4-dimethyl amino pyridine.

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patent: 4772713 (1988-09-01), Nummy et al.
Qing, Li Bao, Research work on synthesis of highly effective acidylation catalytic agent—4-di-methyl amino pyridine, Department of Chemical Industry, Costume Academy, Beijing 100029, 2001 T CH 58, pp. 1-18.
Gen, Xi Guan, et al., Improvement in the method of synthesis of 4-di-methyl amino pyriding, Chemical Reagent, 1998, 20(2), 119-120, 2001 T CH 59.

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