Process for producing 4'-demethyl-epipodophyllotoxin-.beta.-D-et

Details Process for producing 4'-demethyl-epipodophyllotoxin-.beta.-D-et Process for producing 4'-demethyl-epipodophyllotoxin-.beta.-D-et

1983-09-06

1986-01-14

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 41, 536115, C07H 1524

Patent

active

045646759

ABSTRACT:
Disclosed herein are a process for producing 4'-demethyl-epipodophyllotoxin-.beta.-D-ethylidene-glucoside of the formula (II) comprising (A) reacting 4'-halogenoacetyl-4'-demethyl-epipodophyllotoxin-.beta.-D-2,3-di-O-halogen oacetyl-4,6-O-ethylidene-glucoside of the formula (I) with an amine and/or ammonia, or (B) subjecting the acyl-derivative (I) to alcoholysis in the presence of a catalyst, thereby removing the halogenoacetyl groups of the acyl-derivative (I) to obtain the compound (II), the acyl-derivative (I), and the use of the acyl-derivative (I) for synthesizing the compound (II) ##STR1## wherein R represents a halogenoacetyl group represented by the formula

REFERENCES:
patent: 3524844 (1970-08-01), Keller-Juslen et al.
patent: 4147860 (1979-04-01), Farnham et al.
Migrdichian Organic Synthesis, 1957, (p. 12).

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