Process for producing 3-tetrazolyl pyrido[1,2-a]pyrimidine deriv

Details Process for producing 3-tetrazolyl pyrido[1,2-a]pyrimidine deriv Process for producing 3-tetrazolyl pyrido[1,2-a]pyrimidine deriv

1990-02-22

1992-01-14

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

546276, C07D23970

Patent

active

050812432

ABSTRACT:
3-Tetrazolylpyrido[1,2-a]pyrimidin-4-one derivatives useful as an antiallergy agent are produced by reacting a cyano derivative of pyrido[1,2-a]pyrimidin-4-one compound with (i) hydrazoic acid, followed by hydrolysis, or with (ii) a salt of hydrazoic acid, reacting the resulting product with an acid or a base, followed by hydrolysis.

REFERENCES:
patent: 4122274 (1978-10-01), Juby
patent: 4474953 (1984-10-01), Wade
patent: 4816959 (1989-03-01), Matsuishi et al.
Okamoto et al., Chem. Pharm. Bull., 22, 243 (1974).
Journal of Organic Chemistry, vol. 51, No. 15, Jul. 1986, pp. 2988-2994, Washington, D.C., U.S.A.; B. Podanyi et al.: "Nitrogen Bridgehead Compounds 63. Ring-Chain Tautomerism of [(alpha-Azaarylamino)methylene]Malonitriles".
Journal of American Chemical Society, vol. 80, No. 15, Aug. 1958, pp. 3908-3911, Columbus, Ohio, U.S.; W. G. Finnegan et al.: "An Improved Synthesis of 5-Substituted Tetrazoles".

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