Process for producing 3-oxocarboxylic acid esters

Details Process for producing 3-oxocarboxylic acid esters Process for producing 3-oxocarboxylic acid esters

1997-05-23

1999-08-31

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 51, C07C 6966, C07C 6976

Patent

active

059455594

ABSTRACT:
A novel process for producing 3-oxocarboxylic acid esters, which are useful as intermediates in the synthesis of ceramides to be used as a humectant, biodegradable polymers, drugs, etc., at a high purity and a high yield without requiring any troublesome procedure, is disclosed. The process comprises reacting an acetoacetic ester with a calcium compound, a barium compound or a strontium compound in the presence of an organic solvent at a temperature of 10 to 120.degree. C., further reacting the obtained product with a carboxylic acid chloride to thereby acylate it, and then adding thereto an alcohol in an amount 1 to 5 times by mol as much as the calcium compound, barium compound or strontium compound to thereby deacetylate the same.

REFERENCES:
patent: 4820745 (1989-04-01), Muller et al.
patent: 4822829 (1989-04-01), Muller et al.
patent: 5144057 (1992-09-01), Eyer
patent: 5194671 (1993-03-01), Meier
Chem. Rev. 1995, 95, 1065-114.
Helvetica Chimica Acta. Volummen XXXV, Fasciculus VII (1952)--No. 284. p. 2280.

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