Process for producing 2-fluoro-4-(trifluoromethyl) acetanilide

Details Process for producing 2-fluoro-4-(trifluoromethyl) acetanilide Process for producing 2-fluoro-4-(trifluoromethyl) acetanilide

1992-11-19

1994-03-08

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564215, 564217, C07C23315

Patent

active

052929523

ABSTRACT:
Disclosed is a process for producing 2-fluoro-4-(trifluoromethyl) acetanilide which comprises reacting 3,4-difluorobenzotrifluoride with acetamide in the presence of a base in an aprotic polar solvent or in a mixture of an aprotic polar solvent and an aprotic non-polar solvent.

REFERENCES:
patent: 5025107 (1991-06-01), Chamberlin
Harland et al., Synthesis, Nov. 1984, 941-943.
Aldrich et al, J. Med. Chem., 1971, 14, 535-543.
Kagaku Yogo Jiten (Dictionary of Chemical Terms), Third Edition, May 16, 1992, p. 684.

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