Process for producing 2-(carboxyphenyl)-4-quinolinecarboxylic ac

Details Process for producing 2-(carboxyphenyl)-4-quinolinecarboxylic ac Process for producing 2-(carboxyphenyl)-4-quinolinecarboxylic ac

1995-10-27

1998-07-14

Grumbling, Matthew V.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546181, C07D21514

Patent

active

057806349

ABSTRACT:
Quinolin-2-yl benzoic acid compounds which are useful as intermediates of quinoline compounds having angiotensin II antagonist activity prepared by decarboxylating 2-(carboxyphenyl)-4-quinolinecarboxylic acid compounds in which a carboxyl group bonded to a phenyl group may be esterified, while a carboxyl group bonded to a quinoline ring is not esterified, and both rings may have one or more substituents inert to the decarboxylation reaction.

REFERENCES:
patent: 5371227 (1994-12-01), Cremer et al.
patent: 5478832 (1995-12-01), Inoue et al.
Carini et al., "Nonpeptide Angiotensin II Receptor Antagonists: Antihypertensives", J. Med. Chem., 33:5:1330-1336, 1990.

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