Process for producing 2-acylthiophene compound

Details Process for producing 2-acylthiophene compound Process for producing 2-acylthiophene compound

2004-12-13

2010-02-09

Padmanabhan, Sreeni (Department: 1617)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C549S070000, C514S438000, C514S448000

Reexamination Certificate

active

07659411

ABSTRACT:
The present invention provides a process for producing a 2-acylthiophene compound which has a low content of the 3-isomer generated as a by-product, the process comprising reacting a thiophene compound represented by formula (1):wherein R1is a hydrogen atom, a C1-6alkyl group, a phenyl group, or a halogen atom, with at least one member selected from the group consisting of acid anhydrides represented by formula (2):wherein R2is a C1-6alkyl group or a phenyl group, and acid halides represented by formula (3):wherein R2is as defined above and X is a halogen atom, in the presence of a solid acid catalyst at a temperature less than 75° C. in the absence of solvent, thus producing a 2-acylthiophene compound represented by formula (4):wherein R1and R2are as defined above.

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