Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1990-02-26
1991-11-26
Rotman, Alan L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
546345, C07D213643, C07D21364, C07D21326
Patent
active
050683365
ABSTRACT:
A process of producing 2-(4'-hydroxyphenoxy)-3-chloro-5-trifluoromethylpyridine with high efficiency, which is suited for industrial scale production is disclosed. In the process of the present invention, hydroquinone, a dehydrohalogenating agent in the amount of 0.10-0.70 equivalent of the hydroquinone, and a mixed solvent of a polar aprotic solvent and an aromatic hydrocarbon solvent are mixed. The resulting mixture is then heated to reflux at atmospheric pressure to dehydrate the mixture. Then 2,3-dichloro-5-trifluoromethylpyridine in the amount of 0.20-0.95 equivalent of the dehydrohalogenating agent is added to the mixture, and the resulting mixture is allowed to react at a temperature of 100.degree.-170.degree. C.
REFERENCES:
patent: 4410701 (1983-10-01), Krauss
Chemical Abstracts, vol. 95, (15), Abst. No. 132,686-z, Oct. 12, 1981.
Chemical Abstracts, vol. 98, (23), Abst. No. 198,027d, Jun. 6, 1983.
Kitalla, Dimethylformamide Chemical Uses, pp. 6, 8, 33, 36, 60, 90, published by E. I. DuPont de Nemours and Co., 1967 (Wilmington, Del.).
Kagawa Takumi
Morooka Takashi
Tsuzuki Kenji
Rotman Alan L.
Tosoh Corporation
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