Process for producing 17-acetals of 3-alkoxyestra-2,5(10)-dien-1

Details Process for producing 17-acetals of 3-alkoxyestra-2,5(10)-dien-1 Process for producing 17-acetals of 3-alkoxyestra-2,5(10)-dien-1

1977-04-19

1978-10-24

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603975, C07J 2100

Patent

active

041220803

ABSTRACT:
17-Acetals of 3-alkoxyestra-2,5(10)-dien-17-ones are prepared by reacting 17-acetals of 3-alkoxyestra-1,3-5(10)-trien-17-ones with sodium or potassium, liquid ammonia and a tertiary alcohol in the presence of a solvent selected from the group consisting of tetrahydrofuran, dioxane and tetrahydropyran.
Yield and selectivity of this reaction are improved by using the 17-acetals of the 3-alkoxyestra-1,3,5(10)-trien-17-ones, sodium or potassium, liquid ammonia and the solvent in such proportions that the 17-acetals of the 3-alkoxyestra-1,3,5(10)-trien-17-ones are substantially dissolved in the reaction system and that two liquid phases are formed, the lower phase being colored.

REFERENCES:
fried et al. "Organic Reactions in Steroid Chemistry".

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