Process for producing 17-acetals of 3-alkoxyestra-2,5 (10)-dien-

Details Process for producing 17-acetals of 3-alkoxyestra-2,5 (10)-dien- Process for producing 17-acetals of 3-alkoxyestra-2,5 (10)-dien-

1977-11-21

1979-03-06

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603975, C07J 1700

Patent

active

041430409

ABSTRACT:
17-Ketals of 3-alkoxyestra-2,5(10)-dien-17-ones are prepared by reacting 17-ketals of 3-alkoxyestra-1,3,5(10)-trien-17-ones with sodium or potassium, liquid ammonia and a tertiary alcohol in the presence of an alicyclic hydrocarbon and/or an aliphatic hydrocarbon, and a solvent selected from the group consisting of tetrahydrofuran, dioxane and tetrahydropyran.
Yield and selectivity of this reaction are improved by using the 17-ketal of the 3-alkoxyestra-1,3,5(10)-trien-17-one, sodium or potassium, liquid ammonia and the solvent in such proportions that the 17-ketal of the 3-alkoxyestra-1,3,5(10)-trien-17-one is substantially dissolved in the reaction system and that two liquid phases are formed, the lower phase being colored.

REFERENCES:
organic Reactions in Steroid Chemistry by Fried et al., (1972) Van Nostrand Reinhold Company, New York, N.Y., pp. 51 and 58.

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