Process for producing 13-cis retinoic acid

Details Process for producing 13-cis retinoic acid Process for producing 13-cis retinoic acid

1998-03-25

2000-09-26

Padmanabhan, Sreeni

Organic compounds -- part of the class 532-570 series

Organic compounds

Fatty compounds having an acid moiety which contains the...

554126, 554129, 554148, C07C 51353

Patent

active

061244856

ABSTRACT:
The process of the present invention relates to a process for producing 1 3-cis retinoic acid. The process of the present invention involves reacting a Wittig salt in a solvent with a butenolide in the presence of a weak base and a Lewis acid.

REFERENCES:
patent: 4556518 (1985-12-01), Lucci
patent: 4556578 (1985-12-01), Meyer
patent: 4916250 (1990-04-01), Babler
patent: 5061819 (1991-10-01), Babler
patent: 5191110 (1993-03-01), Solladie et al.
patent: 5424465 (1995-06-01), John et al.
Tetrahedron Letters, 29(2):209-212 (1988).

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