Process for producing 1-substituted tetrahydroquinazolines

Details Process for producing 1-substituted tetrahydroquinazolines Process for producing 1-substituted tetrahydroquinazolines

1996-11-13

1998-05-26

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544284, C07D23972, C07D40100, C07D41300, C07D41900

Patent

active

057567387

ABSTRACT:
A process for producing 1-substituted tetrahydroquinazolines represented by the formula (III): ##STR1## as defined herein which comprises reacting tetrahydroquinazolines represented by the formula (I): ##STR2## with hexamethyldisilazane; and reacting the resultant product with a chloroalkanoate represented by the formula (II):

REFERENCES:
Patent Abstracts of Japan, vol. 13, No. 205 (C-595), 15 May 1989 & JP 01 025767 A (Fujisawa Pharmaceutical Co., Ltd.), 27 Jan. 1989.
Susse M. & Johne S., Monatshefte Fur Chemie/Chemical Monthly, vol. 118, No. 1, 1987, pp. 71-79, XP000650958.
Billon F. et al., "Aldose reductase inhibition by 2,4-oxo and thioxo derivatives of 1,2,3,4-tetrahydroquinazoline" European Journal of Med. Chem., vol. 25, No. 2, 1990, pp. 121-126, XP000650960.
Patent Abstracts of Japan, vol. 16, No. 13 (C-901), 14 Jan. 1992 & JP 03 232885 A (Fujisawa Pharmaceutical Co., Ltd.), 16 Oct. 1991.
El-Barbary A.A. et al., Liebigs Annalen Der Chemie, vol. 7, 1995, pp. 1371-1375, XP000651048, "Synthesis and antiviral evaluation of 3'-fluoro-3'-deoxythymidine (FLT)".

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