Process for preparing α,...

Details Process for preparing α,... Process for preparing α,...

2007-09-11

2007-09-11

Page, Thurman K. (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C556S042000

Reexamination Certificate

active

11288530

ABSTRACT:
The invention relates to a novel process for hydroxymethylating noncyclic α,α-dialkylcarboxylic acid derivatives with formaldehyde using amide bases at temperatures of from −40° C. up to the boiling point of the solvent or solvent mixture used.

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patent: 692 25 897 (1998-10-01), None
Clive et al., “Synthesis of the Racemic Tetracyclic Core of CP-225,917: Use of a strain-=assisted Cope rearrangement”; Tetrahedron Letters 43 (2002), pp. 4559-4563.
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Ziegler et al., “Formation of 9, 10-Unsaturation in the Mitomycins: Facile Fragmentation of β-Alkyl-β-aryl-α-oxo-γ-butyrolactones”, Organic Letters, 2000, vol. 2, No. 23, pp. 3619-3621.
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Derwent Abstract corres. to DE 692 25 897 T2.
Kuwajima et al., “A Convenient Method For The Preparation Of β-Hydroxy Esters”, Tetrahedron Letters, No. 26, pp. 2253-2256. 1976.

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