Process for preparing well crystallized alkali metal salts of 3,

Details Process for preparing well crystallized alkali metal salts of 3, Process for preparing well crystallized alkali metal salts of 3,

1990-11-20

1992-08-25

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540215, 540228, C07D50112

Patent

active

051420422

ABSTRACT:
A process for preparing a well crystallized alkali metal salt of 3, 7-substituted 7-aminocephalosporanic acid derivatives having the general formula: ##STR1## wherein: R1= ##STR2## R.sup.2 =CH3 or C1 M=Na or K
from the acid-form derivatives. The process includes preparing a 30% suspension by weight of the acid-form derivative in concentrate alcohol containing 3 to 7% of water by weight, and add an alcoholic solution of alkali base to the suspension under room temperature. The alcohol used to dissolve the base also contains 3 to 7% of water. After a reaction time of 5 to 20 minutes, cool the mixture and let the salt crystallize, and separate the latter from the liquid phase.

REFERENCES:
patent: 3822256 (1974-07-01), Granatek et al.
patent: 4912211 (1990-03-01), Bonfanti

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