Process for preparing water soluble diterpenes and their...

Details Process for preparing water soluble diterpenes and their... Process for preparing water soluble diterpenes and their...

2005-11-01

2005-11-01

Drodge, Joseph (Department: 1723)

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

C023S299000, C210S767000, C424S400000, C424S484000, C424S725000, C514S455000, C514S909000, C514S913000, C516S204000

Reexamination Certificate

active

06960300

ABSTRACT:
Aqueous solutions of diterpenes such as Forskolin, its congeners, analogs and derivatives, up to approximately 6% concentration, are prepared using suitably substituted cyclodextrin as a solubilizing agents. In the absence of cyclodextrin, some diterpenes such as Forskolin are soluble in water only to concentrations of about 0.001%. Such aqueous solutions find applications in topical and systemic use, as pharmaceutical, cosmeceutical, nutraceutical preparations containing diterpenes such as Forskolin and congeners.

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patent: 6471972 (2002-10-01), Bonte et al.
patent: 6540895 (2003-04-01), Spence et al.

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