Process for preparing urokinase complex

Details Process for preparing urokinase complex Process for preparing urokinase complex

1983-11-15

1985-08-20

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

435215, 514 2, 260112R, A61K 3748, A61K 3700, C07G 700, C12N 972

Patent

active

045363919

ABSTRACT:
This invention provides a process for preparing a fibrin-adsorable protein-urokinase complex characterized by reacting a protein adsorbable by fibrin with urokinase in the presence of a protein coupling reagent represented by the formula ##STR1## wherein R is phenylene or cycloalkylene, A is lower alkylene, B is lower alkylene which may optionally be substituted by lower alkylthio or phenyl-lower alkylthio, and l, m and n are each 0 or 1 provided that l, m and n are not 0 at the same time.
The complex is useful as a thrombolytic agent.

REFERENCES:
patent: 4029767 (1977-06-01), Vairel et al.
patent: 4349630 (1982-09-01), Maximenko et al.

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