Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-10-09
2011-12-13
Chung, Susannah (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C548S253000
Reexamination Certificate
active
08076492
ABSTRACT:
A process for the preparation of trityl olmesartan comprising (a) condensing 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazol-5-carboxylic acid alkyl ester with trityl biphenyl bromide in the presence of a polar aprotic solvent and a base selected from the group consisting of alkali metal carbonates, alkali metal hydroxides, alkali metal alkoxides, and tertiary amines to obtain a compound of formula V,b) deesterifying the compound of formula (V) with a base; and c) reacting the product of step (b) with 4-halomethyl-5-methyl-2-oxo-1,3-dioxolene of formula (IV),wherein X is halogen selected from F or Cl or Br or I, to obtain trityl olmesartan medoxomil of formula. The trityl olmesartan medoxomil may be deprotected to produce olmesartan medoxomil.
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Yu, Xin-Hong, et al., “Synthesis of a novel angiotensin II receptor antagonist olmesartan medoxomil,” XP009093461, Zpril 2005, pp. 189-192, vol. 31, No. 2, J. East China Univ. Sci & Tech. (Also see IDS filed May 20, 2009, NPL cite #3).
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Yu, Xin-Hong, et al., “Synthesis of a novel angiotensin II receptor antagonist olmesartan medoxomil,” XP009093461, Apr. 2005, pp. 189-192, vol. 31, No. 2, Journal of East China University of Science and Technology (Natural Science Edition).
Kankan Rajendra Narayanrao
Pathi Srinivas Laxminarayan
Puppala Ravikumar
Rao Dharmaraj Ramachandra
Carroll Rodney B.
Chung Susannah
Cipla Limited
Conley & Rose, P.C.
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