Process for preparing thiophene derivatives

Details Process for preparing thiophene derivatives Process for preparing thiophene derivatives

1980-01-07

1981-05-05

Siegel, Alan

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D33324

Patent

active

042660670

ABSTRACT:
Process for the preparation of a series of thiophene derivatives, from which 2-thiopheneacetic acid derivatives can easily be prepared, in high yields and selectivity by using substituted or unsubstituted 2-acetylthiophenes as the starting materials by easy operations. 2-Thiopheneacetic acid derivatives are very useful compounds as the chemical modifier of penicillin and cephalosporin. In the course of the reaction, 2-(dihaloacetyl)thiophenes are formed which are valuable intermediates for the production of not only 2-thiopheneacetic acids but also thioprofenic acid which is known as an anti-inflammatory agent.

REFERENCES:
patent: 3013079 (1961-12-01), Pearson
Reeve, JACS, 83, 2755 (1961).
Kieboom, Chem. Abst., 74, 99173.
Brunswig, Berichte, 19, pp. 2890-2896, (1886).

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