Process for preparing thiazolobenzimidazoles and intermediates u

Details Process for preparing thiazolobenzimidazoles and intermediates u Process for preparing thiazolobenzimidazoles and intermediates u

1987-12-23

1989-03-14

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548149, C07D51304

Patent

active

048125741

ABSTRACT:
The invention concerns a process for preparing a thiazolo[3,2-a]benzimidazole of formula I ##STR1## in which formula n is 1 or 2, and R.sub.1 is hydrogen, lower alkyl, lower alkoxy, trifluoromethyl or halo, or a salt thereof which comprises dehydrating a compound of formula II, ##STR2## or a salt thereof wherein n and R, are as defined above, and COOR is an acid or ester function in the presence of an acid selected from sulphuric, sulphonic and phosphoric acid or mixtures thereof and if desired or required an inert solvent provided that if water is present then the amount of water is less than about 15% by volume of the acid, the reaction being carried out with heating if necessary.

REFERENCES:
patent: 4214089 (1980-07-01), Fenichel et al.
patent: 4361574 (1982-11-01), Grant et al.
Abstract--J. Med. Chem., 1976, vol. 19, No. 4m, S. C. Bell & P. H. L. Wei.
Weygand, Preparative Organic Chemistry, pp. 813-819, (1972).
March, Advanced Organic Chemistry, pp. 901-903, (1985).
Maulding, J. Pharm. Sci., 66, 1175, (1977).

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